Swedish and German scientists found a new compound for optimal anticancer drug



Researchers at the Max Planck Institute for Aging Biology in Cologne, Karolinska Institute, Stockholm, Sweden recently said: They have just developed a new compound that blocks the reading of genetic information in mitochondria in order to make destroying cancer cells.

This compound could be used as a potential anti-tumor drug in the future.

Swedish and German scientists found a new compound for optimal anticancer drug

A new compound to create an optimal anticancer drug / ph: instagram@biomedicina_descomplicada

 Mitochondria provide cells with the energy and cell builders needed for the normal function of tissues and organs.  Cancer stem cells are highly dependent on mitochondrial metabolism.  While drugs that target mitochondrial function are often very toxic, and very difficult to target mitochondria.

 In the new study, a group of Swedish and German scientists have found a way to overcome these difficulties.  By creating a potential anticancer drug that targets mitochondrial function without serious side effects and without harming healthy cells.

Mitochondria contain their own genetic material, the DNA molecules located in the mitochondria (mtDNA), which are mediated by a set of specialized proteins.  One such protein is the enzyme mitochondrial RNA polymerase (POLRMT).

 The team designed a test method to help identify the chemical compound that inhibits POLRMT.  POLRMT inhibitors, essentially starve the cancer cells without causing toxic side effects, at least for a certain period of time, while also dramatically reducing the viability of cancer cells and tumor growth in the body.

With an important role of metabolism in the mitochondria cells, the mitochondrial gene expression inhibitor can be used as a tool in many different fields, opening up new trends in development for anticancer drugs.  The study also gave scientists a deeper understanding of the cellular effects of mitochondrial dysfunction and mitochondrial diseases.  This is considered a new step in research on genes and cells.

Swedish and German scientists found a new compound for optimal anticancer drug

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