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Scientists Find How to Reverse Wrinkles and Hair Loss from Ageing

April 09, 2020

Scientists have published a research on mitochondrial depletion carried out in mice. The research could be the key to reducing the signs of aging such as wrinkles and hair loss.

 

As we age, we are less able to have new blood vessels in the muscles, hence reducing our ability to do endurance exercise and causing the weakness and fragility. Researchers find the similar changes in other mammals like mice.
During the study, researchers activated a mutation in mice that may cause their mitochondrial function to drop. Therefore, the mice developed wrinkles and had hair loss and greying hair within two months. In only 4 weeks, the mice started to have hair loss, gray hair and they also became lethargic. In 4-8 weeks, the mice started to develop wrinkles. Besides, the female mice were found to show more severe wrinkles than male mice. The wrinkles look like those caused by both natural process of aging and by smoking or sun exposure.
Nonetheless, when the researchers switched off the gene mutation, all of these signs of aging were reduced and reserved. The results show that epigenetic mechanisms that underlie mitochondria-to-nucleus cross-talk are very important for the reconstruction of normal hair and skin phenotype.
In cells, about 90% of the chemical energy cells are produced by the mitochondria. As we age, their mitochondrial function will be declined. This condition can lead to many signs of aging such as hair loss and wrinkles. When the body loses mitochondrial DNA, it can cause some certain diseases like cancer, cardiovascular disease, neurological disorders and diabetes that result from age.

However, there is no guarantee that the results are as same as in humans. Also, there is no guarantee that the chemicals used on the mice would be safe in humans as well.

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