Can Low Progesterone cause Miscarriage?



High progesterone during pregnancy is the cause of unpleasant "side effects".  However, do not rush to hate these pregnancy hormones, mom!  Without them, pregnant women will face a high risk of miscarriage in the first months of pregnancy. So Can Low Progesterone cause Miscarriage? The answer is Yes.

Can Low Progesterone cause Miscarriage?

1- Effects of Progesterone on pregnancy

 - Regulate menstrual cycle
 - Affects the process of "nesting" for eggs
 - Increases body temperature during ovulation and during "red light" days

- Increase arterial blood and glycogen in the uterine lining to ensure nutrients for the fetus
 - Creates cervical mucus plug to avoid bacterial invasion
 - Prevent uterine contractions

Can Low Progesterone cause Miscarriage?

Can Low Progesterone cause Miscarriage? / ph: pexels

2- Changes in the hormone progesterone during early pregnancy

- The 1st- 2nd week of pregnancy:

During this time, the amount of progesterone hormone from the ovaries is about 1-1.5 ng/ml.  Progesterone helps prepare your body for a healthy pregnancy.  In most cases, ovulation will be completed within the first 2 weeks of pregnancy.

- The 3rd – 4th week of pregnancy:

After ovulation, the endocrines in the ovaries will begin to produce progesterone at a level of 2 ng/ml or higher in preparation for conception. During the 3rd week, the egg is released.  will be fertilized and this process increases progesterone levels in the body to about 1-3 ng/ml per day and can peak to 10-29 ng/ml.

– The 5th-6th week of pregnancy:

This stage, the hormone progesterone has reached 10-29 ng/ml per day.  With the main task of nourishing the placenta, stimulating the growth of uterine blood vessels and helping the placenta work, progesterone contributes to a stable and healthy pregnancy.  However, the high level of progesterone during this period can cause some "side effects" for pregnant women, such as itchy skin.

- The 7th-14th week of pregnancy:

During this period, the placenta will begin to "take the throne", replacing the ovaries that produce progesterone.  Therefore, progesterone levels are especially high at this stage, especially for women carrying twins or multiples.  Normally, progesterone levels in this stage are around 15-60ng/ml and have the effect of relaxing the muscles, creating more space for the baby to develop.  This also helps prevent contractions too early in pregnancy.  However, the level of progesterone is the main "culprit" of constipation, heartburn and indigestion in pregnant women.

Depending on the trimester, progesterone levels will fluctuate at the following levels:
 – First trimester: 9-47 ng/ml
 – 2nd trimester: 17-147 ng/ml
 – 3rd trimester: 55-200 ng/ml

3- Can Low Progesterone cause Miscarriage?

To avoid ectopic pregnancy or miscarriage, progesterone is measured continuously during the first 3 months of pregnancy.  According to research, a progesterone level at 6 weeks of pregnancy between 6-10 ng/ml indicates an unsafe pregnancy.  If you are worried about your progesterone levels, you can order the necessary tests.  Women who have had a history of miscarriage during the first 20 weeks of pregnancy may need progesterone therapy to prevent a repeat.

Low Progesterone levels are one of the leading causes of miscarriage.  Decreased Low Progesterone levels can lead to shedding of the lining of the uterus, causing bleeding.  If blood streaks appear along with strong contractions, pregnant women should go to the hospital immediately.  These are common signs of a miscarriage.

The cases of Low Progesterone levels can be treated with vaginal suppositories, pills, injections, etc. Depending on each person's physical condition, the doctor will give different treatment directions.

Can Low Progesterone cause Miscarriage?

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